The Role of Growth Factors in Skin Healing and Rejuvenation

Traditional topically applied treatments for reversing the signs of aging and photo-damage in skin utilize various ingredients that have limited benefits but do not actively mimic the natural functions of the skin. Growth factor biotechnology has enabled an entirely new, revolutionary method of restoring aging and photo-damaged skin to a more youthful state: replenishing the naturally occurring biological elements that are present in young, undamaged skin to re-activate the skin’s youthful functions.

Growth factors are signaling proteins produced by stem cells in the epidermis. They travel through the layers of the skin, keeping skin cells active and nourished. Growth factors regulate the biological activities responsible for repairing cellular and genetic damage and maintaining the skin’s smooth, firm, healthy appearance. Production of growth factors, and thus the repair and maintenance activities they stimulate, slows down as skin ages and suffers years of environmental and photo damage. Collagen and elastin are destroyed faster than fibroblasts can replace stores of these fibers, which provide firmness and elasticity to the skin. Repair and new cell generation become less effective, so the skin is more susceptible to damage becoming permanent and visible in the form of rhytides, sagging skin, and hyperpigmentation.

Clinical trials of artificial skin grafts for burns and other serious wounds have long shown the benefits of applying healthy, normal skin with youthful levels of growth factors to damaged areas. The growth factors are the primary mechanisms in generating new, healthy skin. The visible manifestations of aging and photo-damage are, essentially, wounds that the skin is unable to heal completely due to a sub-optimum level of growth factors to activate the regeneration process.